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Discussion While GLP-1RAs hold considerable promise for ophthalmic disorders, particularly DR and glaucoma, significant hurdles remain in translating preclinical findings into routine clinical practice

Challenges include side effects, lack of insurance coverage for off-label conditions and high out-of-pocket costs

554 Astrocyte pathology is a fundamental, if not leading, factor in neuronal death: astrocytes in ALS lose their capability to sustain neurones, to clear glutamate and they some aberrant astrocytic forms are generated, which may cause direct damage

Harvard Medical School

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